Jerne was the first to suggest the now generally accepted explanation
of the way in which the immune system produces antibodies to match any
possible bacterium, virus, or other type of antigen (invading body).
He also offered a comprehensive theory of the development of the immune
system as a whole, and in 1974 he presented the so-called network theory,
in which he detailed the complex system of interactions whereby the
immune system is activated to respond to and counteract disease and
then is shut down when it is not needed.
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