Vane and his two colleagues received the Nobel Prize for their isolation, identification, and analysis of prostaglandins, biochemical compounds that influence blood pressure, body temperature, allergic reactions, and other physiological phenomena in mammals. In demonstrating that aspirin inhibits the formation of prostaglandins associated with pain, fever, and inflammation, Vane provided a physiological rationale for the effectiveness of the world's most widely used drug. In 1986 Vane founded the William Harvey Research Institute, which funded
cardiovascular research. He was knighted in 1984. |
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